Pleurotus nebrodensis Mushroom (Agaricomycetes) Polysaccharide Chewable Tablets Alleviate Adenine-Induced Chronic Kidney Disease: Efficacy Assessment and Formulation Optimization.

Chronic kidney disease (CKD), a pathological status characterized by progressive structural and functional deterioration, has emerged as a major global health concern, necessitating urgent attention and effective interventions. This study aimed to characterize Pleurotus nebrodensis polysaccharide (PNPS) and develop a novel P. nebrodensis polysaccharide chewable tablet (PNPT). Briefly, the optimal formulation of PNPT was determined as 20% PNPS, 40% maltose, 0.4% magnesium stearate, 0.2% citric acid, and 39.6% mannitol, respectively. In the mouse experiment, PNPT at both 300 and 600 mg/kg/d dosages showed potential therapeutic efficacy by improving renal function, enhancing antioxidant activity, and inhibiting inflammatory responses. The findings suggested that the PNPS could be used as dietary supplements to develop appropriate products for alleviating CKD and its complications.