Science advances · 2026
A helix-loop-helix gene orchestrates male fate in common carp.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen Kuangxin, Chen Ji, Ding Miao, Rong Yi, Guo Yuanqi, Li Yongming, Tao Binbin, Song Yanlong, Wu Xingxing, Chen Lei, Li Rui, Jiang Mouyan, Li Zhaoxian, Jia Shaoting, Wu Yunya, Wei Yulai, Jiang Yinjun, Liu Hairong, Ji Shuhui, Ma Wenge, Shan Xishuang, Zhong Wenrong, Xu Wen, Liao Xianyao, Chen Lu, Zhang Xiya, Luo Junzhi, Cui Xuefan, Luo Hongrui, Liu Fei, Wang Houpeng, Qiao Zhixian, Chai Xiaocui, Zhou Fang, Luo Daji, He Shunping, Zhu Zuoyan, Trudeau Vance L, Ge Chutian, Hu Wei
Аннотация
Fish show exceptional diversity in sex-determination mechanisms, making them a powerful system for studying how these pathways evolve. However, no definitive master sex-determining gene has yet been identified in Cyprinidae, a widely distributed and species-rich fish family. Here, we identified a male-specific gene in common carp encoding Pangu, a helix-loop-helix (HLH) domain peptide localized to Sertoli cells. Loss- and gain-of-function analyses demonstrate that pangu is both necessary and sufficient for male sex determination. Expression and reporter assays indicate that pangu represses cyp19a1a, a key regulator of ovarian differentiation, and disruption of cyp19a1a restores testicular development in the feminized phenotype of XY pangu mutants. These findings establish pangu as the master sex-determining gene in common carp and link an HLH domain peptide to sex differentiation.