Burns : journal of the International Society for Burn Injuries · 2026
White noise as a non-pharmacological intervention for enhancing the recovery of rats with wound-associated sleep disorders.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Wen Shiqi, Huang Liping, Li Jiafei, Ullah Hanif, Chen Yuwen, Li Ka
Аннотация
OBJECTIVE: Sleep disorders are one of the common symptoms in patients with wounds, which can hinder recovery. Commonly used hypnotic medications in clinical practice are short-acting but carry risks of adverse reactions and drug abuse. As a non-invasive acoustic intervention, white noise can regulate brain electroencephalographic rhythms to improve sleep disorders. However, the interventional effects and rehabilitation outcomes of white noise on wounds with sleep disorders remain unclear.
METHOD: A wound model with sleep disorders was established in rats by integrating para-chlorophenylalanine-induced sleep deprivation with full-thickness skin excision. The rats were randomly allocated into three groups: white noise (WN), alprazolam (ALP), and control (Model). Sleep status was evaluated using pentobarbital supra-threshold dose synergistic sleep tests, circadian activity monitoring, and serum 5-hydroxytryptamine (5-HT) level measurements. Inflammatory responses were assessed via blood routine examinations and serological analyses. Histological and immunohistochemical evaluations were performed to examine the structural features of the wounds.
RESULTS: Compared with the control group, the WN group showed significantly reduced sleep latency and inflammatory markers, as well as increased sleep duration, body weight gain rate, and wound healing rate. After prolonged intervention, the newly formed tissue in the WN group exhibited a lower epidermal-dermal ratio, collagen fibers that were orderly and loosely arranged, decreased neovascularization, and thus more closely resembled the morphology of normal skin compared to the Model group.
CONCLUSION: WN promotes the long-term restoration of sleep and body weight in rats with wound-induced sleep disturbances. WN regulates inflammatory responses, facilitating inflammation resolution and expediting the transition to the repair phase.
METHOD: A wound model with sleep disorders was established in rats by integrating para-chlorophenylalanine-induced sleep deprivation with full-thickness skin excision. The rats were randomly allocated into three groups: white noise (WN), alprazolam (ALP), and control (Model). Sleep status was evaluated using pentobarbital supra-threshold dose synergistic sleep tests, circadian activity monitoring, and serum 5-hydroxytryptamine (5-HT) level measurements. Inflammatory responses were assessed via blood routine examinations and serological analyses. Histological and immunohistochemical evaluations were performed to examine the structural features of the wounds.
RESULTS: Compared with the control group, the WN group showed significantly reduced sleep latency and inflammatory markers, as well as increased sleep duration, body weight gain rate, and wound healing rate. After prolonged intervention, the newly formed tissue in the WN group exhibited a lower epidermal-dermal ratio, collagen fibers that were orderly and loosely arranged, decreased neovascularization, and thus more closely resembled the morphology of normal skin compared to the Model group.
CONCLUSION: WN promotes the long-term restoration of sleep and body weight in rats with wound-induced sleep disturbances. WN regulates inflammatory responses, facilitating inflammation resolution and expediting the transition to the repair phase.