Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
Update to RIFM fragrance ingredient safety assessment, ethyl decanoate, CAS Registry Number 110-38-3.
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Api A M, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Friedrich A, Burton G A, Cancellieri M A, Chon H, Cronin M, Crotty S, Dagli M L, Dekant W, Deodhar C, Farrell K, Fryer A D, Guttenberg M, Jones L, Joshi K, Lapczynski A, Laskin D L, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning T M, Piersma A H, Ritacco G, Sadekar N, Schember I, Schultz T W, Siddiqi F, Sipes I G, Sullivan G, Thakkar Y
Аннотация
The existing information supports the use of this material as described in this safety assessment. Ethyl decanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Target data show that ethyl decanoate is not genotoxic. Data on read-across analog ethyl hexanoate (CAS # 123-66-0) provide a calculated Margin of Exposure (MOE) >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across analog methyl octanoate (CAS # 111-11-5) show that there are no safety concerns for ethyl decanoate for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; ethyl decanoate is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to ethyl decanoate is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; ethyl decanoate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients (RQs), based on its current volume of use (VoU) in Europe (EU), North America (NA), Asia-Pacific (AP), Japan (JP), and South America (SA) (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.