Histopathology · 2026
Endocervical gastric-type AIS: a rare histologic finding that further supports the hypothesis of a pyloric-type metaplastic origin.
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Paudice Michele, Parrella Veronica, Scaglione Giulia
Аннотация
BACKGROUND: Gastric-type adenocarcinoma in situ (gAIS) is a rare, HPV-independent precursor of cervical adenocarcinoma with incompletely defined histogenesis.
AIMS: To report a case of gAIS and its association with pyloric-type gastric metaplasia.
MATERIALS AND METHODS: A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.
RESULTS: Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified.
DISCUSSION: The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.
CONCLUSION: This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.
AIMS: To report a case of gAIS and its association with pyloric-type gastric metaplasia.
MATERIALS AND METHODS: A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.
RESULTS: Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified.
DISCUSSION: The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.
CONCLUSION: This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.