Natural product research · 2021
Three quinolinone alkaloid - phenylpropanoid adducts from Melicope pteleifolia.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nguyen Thanh Hoa, Nguyen Thi Hoai Thu, Dang Thi Phuong Thao, Nguyen Pham Anh Thu, Truong Thi Bich Ngoc, Phung Nguyen Kim Phi, Nguyen Thi Anh Tuyet
Аннотация
Preliminary in vitro cytotoxic test on different extracts of Melicope pteleifolia collected at Dăk Nong province, Vietnam showed that the n-hexane one was the most potent. From this n-hexane extract, three new quinolinone alkaloid-phenylpropanoid derivatives (1-3) and three known compounds (4-6) were isolated. Based on NMR and HR-MS analysis, their chemical structures were elucidated as melicoptines A-C (1-3), flindersine (4), 3,4,5-trimethoxybenzoic acid (5) and (24S)-methylcholestan-1α,3β-diol (6). Isolated compounds (1-4) were evaluated for their anti-bacterial and cytotoxic activities against human non-small cell lung cancer (A549), human cervical cancer (HeLa), human Burkitt's lymphoma (Raji) and normal fibroblasts (NIH-3T3). All of them were inactive.