medRxiv : the preprint server for health sciences · 2026
Longitudinal changes of iron in the substantia nigra of early-stage Parkinson's disease.
СтатьяПрепринтНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Du Guangwei, Sica Christopher, De Jesus Sol, Kong Lan, Mailman Richard B, Huang Xuemei
Аннотация
BACKGROUND: Higher iron occurs in the substantia nigra in Parkinson's disease (PD), but its behavior over time is poorly understood.
OBJECTIVE: To determine if nigral iron measured by quantitative susceptibility MRI can track progression of early stages of PD.
METHODS: Thirty-four early-stage PD patients (disease duration < 4 yrs) and 35 matched controls were recruited. Iron content in the substantia nigra and related regions was obtained using quantitative susceptibility mapping with zero-referencing at both baseline and one-year follow-up, along with clinical metrics.
RESULTS: Of five clinic metrics and five regional iron measures, only MDS-UPDRS II (p = 0.046) and SNc iron (p = 0.004) showed significant changes for PD subjects in the one-year epoch. The changes of SNc iron also were correlated with changes of MDS-UPDRS II (p = 0.005).
CONCLUSION: Nigral iron content measured by zero-referencing is sensitive for tracking disease progression in early-stage PD.
OBJECTIVE: To determine if nigral iron measured by quantitative susceptibility MRI can track progression of early stages of PD.
METHODS: Thirty-four early-stage PD patients (disease duration < 4 yrs) and 35 matched controls were recruited. Iron content in the substantia nigra and related regions was obtained using quantitative susceptibility mapping with zero-referencing at both baseline and one-year follow-up, along with clinical metrics.
RESULTS: Of five clinic metrics and five regional iron measures, only MDS-UPDRS II (p = 0.046) and SNc iron (p = 0.004) showed significant changes for PD subjects in the one-year epoch. The changes of SNc iron also were correlated with changes of MDS-UPDRS II (p = 0.005).
CONCLUSION: Nigral iron content measured by zero-referencing is sensitive for tracking disease progression in early-stage PD.