Psychological medicine · 2026
Anterograde and retrograde amnesia following electroconvulsive therapy: A controlled longitudinal study accounting for time and depression.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mathiassen André Beyer, Lundsgaard Christoffer Cramer, Fagerlund Birgitte, Miskowiak Kamilla, Videbech Poul
Аннотация
BACKGROUND: Electroconvulsive therapy (ECT) may be accompanied by amnesia. However, the extent to which different memory subtypes are affected is unclear, as well-controlled longitudinal studies are sparse. We aimed to investigate short- and long-term effects of ECT on different aspects of memory.
METHODS: We recruited patients with depression referred to ECT (n = 31) or other treatment (n = 21) and healthy participants (n = 29). We measured autobiographical (Columbia Autobiographical Memory Interview - Short Form), verbal (Verbal Learning Test - Delayed), and visual (Rey Complex Figure Test) anterograde memory at baseline (T1), post-ECT (T2), and 6-month follow-up (T3). We performed a repeated measures mixed ANOVA for each outcome. An ANCOVA explored whether age and cognitive reserve were associated with severity of amnesia. ClinicalTrials.gov: NCT04160286.
RESULTS: A substantial effect of ECT on autobiographical memory was indicated by a group-by-time interaction, F (3.45, 103.51) = 22.261, p < 0.001, partial η2 = 0.426. The effect remained stable, and inferior to control groups, at T3 (p < 0.001). A large effect of ECT on verbal anterograde memory was suggested by a group-by-time interaction, F (2, 68) = 6.138, p = 0.004, partial η2 = 0.153, reflecting transient impairment after ECT (p = 0.009). No ECT-related decline in visual anterograde memory was observed (p = 1.0). Neither age nor cognitive reserve was associated with degree of amnesia.
CONCLUSIONS: Our findings suggest that ECT may be associated with autobiographical amnesia, potentially lasting at least 6 months, and transient verbal, but not visual, anterograde amnesia.
METHODS: We recruited patients with depression referred to ECT (n = 31) or other treatment (n = 21) and healthy participants (n = 29). We measured autobiographical (Columbia Autobiographical Memory Interview - Short Form), verbal (Verbal Learning Test - Delayed), and visual (Rey Complex Figure Test) anterograde memory at baseline (T1), post-ECT (T2), and 6-month follow-up (T3). We performed a repeated measures mixed ANOVA for each outcome. An ANCOVA explored whether age and cognitive reserve were associated with severity of amnesia. ClinicalTrials.gov: NCT04160286.
RESULTS: A substantial effect of ECT on autobiographical memory was indicated by a group-by-time interaction, F (3.45, 103.51) = 22.261, p < 0.001, partial η2 = 0.426. The effect remained stable, and inferior to control groups, at T3 (p < 0.001). A large effect of ECT on verbal anterograde memory was suggested by a group-by-time interaction, F (2, 68) = 6.138, p = 0.004, partial η2 = 0.153, reflecting transient impairment after ECT (p = 0.009). No ECT-related decline in visual anterograde memory was observed (p = 1.0). Neither age nor cognitive reserve was associated with degree of amnesia.
CONCLUSIONS: Our findings suggest that ECT may be associated with autobiographical amnesia, potentially lasting at least 6 months, and transient verbal, but not visual, anterograde amnesia.