Acute Kidney Injury Following Whole Cherry Consumption as a Sleep Aid in a Geriatric Patient With Chronic Kidney Disease.

Cherries are consumed for their anti-inflammatory and sleep-promoting effects, but their potential adverse effects remain poorly characterized. A 95-year-old woman with stage 3A chronic kidney disease (CKD) presented with an increase in serum creatinine from a baseline of 0.8 to 1.3 mg/dL and a decrease in estimated glomerular filtration rate from 55.3 to 35.2 mL/min/1.73 m² following two weeks of consuming 15-20 fresh or frozen whole cherries nightly. Cherry consumption was discontinued, and her kidney function returned to baseline one month later. Cherries contain high amounts of anthocyanins, which may contribute to acute kidney injury (AKI) in CKD patients through cyclooxygenase (COX)-inhibitory mechanisms, similar to nonsteroidal anti-inflammatory drugs (NSAIDs). Application of the Naranjo Adverse Drug Reaction Probability Scale yielded a score of 7, indicating a "probable" association between cherry consumption and AKI.