[Research progress in modern scientific connotation of compatibility of TCM compound prescriptions based on supramolecular assembly].

The compatibility of TCM compound prescriptions is a core component of the TCM theory. Clarifying the modern scientific connotation of the compatibility theory is of great significance for promoting the modern development and clinical application of TCM compound prescriptions. In recent years, interdisciplinary research between supramolecular chemistry and TCM has gradually become a research hotspot. Studies have confirmed that the chemical components in TCM compound prescriptions can form supramolecular aggregates with specific structures and functions through molecular self-assembly, which serve as an important physical structural basis for the efficacy of TCM compound prescriptions. This can partially unravel the intrinsic mechanisms underlying the holistic synergy, toxicity attenuation, and efficacy enhancement of TCM compatibility. By reviewing the research progress in TCM supramolecular assembly, this paper elaborates on the basic characteristics of TCM supramolecular assembly. Furthermore, this paper systematically reviews the research advances in interpreting the connotations of efficacy enhancement and toxicity attenuation as well as the efficacy attenuation and toxicity enhancement(incompatibility) of the compatibility of TCM compound prescriptions via supramolecular assembly. This review is expected to provide a reference for further clarifying and enriching the modern scientific connotation of the compatibility theory and to promote the modern development and clinical application of TCM compound prescriptions.