[Comparative analysis of chemical constituents between wild and cultivated Paeoniae Radix Rubra from authentic producing areas based on UHPLC-Q-TOF-MS combined with multivariate statistical analysis].

To clarify the similarities and differences in chemical constituents between wild and cultivated Paeoniae Radix Rubra from traditional authentic producing areas, and to investigate the quality status of cultivated Paeoniae Radix Rubra as a new production model of medicinal materials, this study employed ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS) to characterize and identify the chemical constituents in wild and cultivated medicinal materials derived from two original species of Paeoniae Radix Rubra(Paeonia lactiflora and P. veitchii) collected from authentic producing areas in Inner Mongolia and Sichuan. Multivariate statistical analysis was further applied to screen differential components between wild and cultivated samples. A total of 60 chemical compounds were identified from Paeoniae Radix Rubra, including monoterpene glycosides, flavonoids, tannins, phenolic acids, and other structural types. The multivariate statistical analysis showed that there were no obvious differences in the composition profile and overall content between wild and cultivated Paeoniae Radix Rubra, with differences mainly observed in the content of certain components. From a chemical perspective, this study demonstrates the similarity between cultivated and wild Paeoniae Radix Rubra from authentic producing areas and provides a reference for the quality control of cultivated Paeoniae Radix Rubra.