K2S2O8 promoted N-methoxymethylation of benzamides.

Herein, we report a potassium persulfate (K2S2O8) promoted methodology for the selective N-methoxymethylation of benzamides. Utilizing methanol as both the solvent and a sustainable C1 source, the developed protocol exhibits broad functional group tolerance with good to excellent yields. The deuterium-labelling experiment and reported literature suggest a radical-mediated pathway, offering a green, operationally simple approach for the synthesis of N-methoxymethylated benzamides.