Hyocholic acid: a primary bile acid regulating lifespan immunometabolism.

Hyocholic acid (HCA), a newly identified human primary bile acid, regulates glucose and lipid metabolism and maintains immunometabolic homeostasis. This forum article highlights HCA and its derivatives as key mediators of inter-organ crosstalk across the lifespan, underscoring their potential to advance diagnostics and therapeutics for immunometabolic disorders.