Journal of ethnopharmacology · 2026
Neuroprotective efficacy of Nyctanthes arbor-tristis in a rotenone-induced rat model of Parkinson's disease.
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More Aniket, Wagaskar Pooja, Kumari Nishchhal, Suryawanshi Meghraj, Patil Ashwani
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Nyctanthes arbor-tristis is widely used in traditional medicine systems for its anti-inflammatory, antioxidant, and neuroprotective properties. It has been traditionally employed in the management of neurological and inflammatory disorders, supporting its potential role in neurodegenerative conditions such as Parkinson's disease. These therapeutic effects are attributed to its rich phytochemical profile, particularly iridoid glycosides (e.g., Arbortristoside A, nyctanthoside) and flavonoids (e.g., quercetin, kaempferol), which are known to modulate oxidative stress, neuroinflammation, and neuronal survival pathways.
AIM OF THE STUDY: The present study aimed to evaluate the neuroprotective potential of Nyctanthes arbor-tristis leaf extract against rotenone-induced Parkinsonism in an experimental rat model.
MATERIALS AND METHODS: Male Wistar rats were divided into six groups and Parkinsonian symptoms were induced using rotenone (2.5 mg/kg/day, i.p.) for 21 days. The extract of Nyctanthes arbor-tristis (150, 250, and 500 mg/kg) was administered orally. Behavioral assessments included rotarod, beam walk, hanging wire, elevated plus maze, and forced swim test. Biochemical parameters such as catalase, glutathione, lipid peroxidation, NF-kB, and dopamine levels were evaluated. Histopathological analysis and dopaminergic neuronal count were also performed.
RESULTS: Treatment with Nyctanthes arbor-tristis extract significantly produced dose-dependent neuroprotection, with the Test 3 group demonstrating efficacy comparable to standard levodopa-carbidopa therapy. It improved motor coordination and reduced anxiety and depression-like behaviors. It restored antioxidant enzyme levels, decreased lipid peroxidation, and downregulated NF-kB expression. Dopamine levels and dendritic count of dopaminergic neurons were significantly preserved in treated groups. Histopathological findings revealed reduced neuronal degeneration and gliosis, particularly at higher doses.
CONCLUSIONS: Nyctanthes arbor-tristis exhibited dose-dependent neuroprotective effects against rotenone-induced Parkinsonism, likely mediated through antioxidant, anti-inflammatory, and dopaminergic neuronal preservation mechanisms. These findings support its potential as a safe and effective therapeutic candidate for the management of Parkinson's disease, warranting further pharmacological and clinical investigations.
AIM OF THE STUDY: The present study aimed to evaluate the neuroprotective potential of Nyctanthes arbor-tristis leaf extract against rotenone-induced Parkinsonism in an experimental rat model.
MATERIALS AND METHODS: Male Wistar rats were divided into six groups and Parkinsonian symptoms were induced using rotenone (2.5 mg/kg/day, i.p.) for 21 days. The extract of Nyctanthes arbor-tristis (150, 250, and 500 mg/kg) was administered orally. Behavioral assessments included rotarod, beam walk, hanging wire, elevated plus maze, and forced swim test. Biochemical parameters such as catalase, glutathione, lipid peroxidation, NF-kB, and dopamine levels were evaluated. Histopathological analysis and dopaminergic neuronal count were also performed.
RESULTS: Treatment with Nyctanthes arbor-tristis extract significantly produced dose-dependent neuroprotection, with the Test 3 group demonstrating efficacy comparable to standard levodopa-carbidopa therapy. It improved motor coordination and reduced anxiety and depression-like behaviors. It restored antioxidant enzyme levels, decreased lipid peroxidation, and downregulated NF-kB expression. Dopamine levels and dendritic count of dopaminergic neurons were significantly preserved in treated groups. Histopathological findings revealed reduced neuronal degeneration and gliosis, particularly at higher doses.
CONCLUSIONS: Nyctanthes arbor-tristis exhibited dose-dependent neuroprotective effects against rotenone-induced Parkinsonism, likely mediated through antioxidant, anti-inflammatory, and dopaminergic neuronal preservation mechanisms. These findings support its potential as a safe and effective therapeutic candidate for the management of Parkinson's disease, warranting further pharmacological and clinical investigations.