Movement disorders clinical practice · 2026
Socio-Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Imbalzano Gabriele, Montanaro Elisa, Giacchero Martina, Ledda Claudia, Romagnolo Alberto, Rizzone Mario Giorgio, Lopiano Leonardo, Zibetti Maurizio
Аннотация
BACKGROUND: Socio-occupational functioning in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) is not fully captured by standard motor and quality-of-life scales.
OBJECTIVES: To characterize patient-reported socio-occupational functioning after STN-DBS and explore associated clinical and demographic factors.
METHODS: Thirty-four PD patients were assessed 9-18 months postoperatively using a semi-structured interview covering socio-occupational domains. A composite mean score (Q_mean) was computed as a descriptive index, with clinical associations explored using univariate screening and multivariate linear regression.
RESULTS: The Q_mean score following STN-DBS was 7.66 ± 0.86 (range 6.00-9.57). In exploratory multivariate analysis, female sex (n = 7) was associated with higher functioning (P = 0.003), whereas GBA variants (n = 5) with lower functioning (P = 0.007).
DISCUSSION: Perceived socio-occupational functioning was overall satisfactory at postoperative assessment, with limited association with conventional motor/neuropsychiatric measures, and greater association with individual factors such as sex and genetic background. These exploratory findings support inclusion of socio-occupational perspectives in DBS outcome evaluation.
OBJECTIVES: To characterize patient-reported socio-occupational functioning after STN-DBS and explore associated clinical and demographic factors.
METHODS: Thirty-four PD patients were assessed 9-18 months postoperatively using a semi-structured interview covering socio-occupational domains. A composite mean score (Q_mean) was computed as a descriptive index, with clinical associations explored using univariate screening and multivariate linear regression.
RESULTS: The Q_mean score following STN-DBS was 7.66 ± 0.86 (range 6.00-9.57). In exploratory multivariate analysis, female sex (n = 7) was associated with higher functioning (P = 0.003), whereas GBA variants (n = 5) with lower functioning (P = 0.007).
DISCUSSION: Perceived socio-occupational functioning was overall satisfactory at postoperative assessment, with limited association with conventional motor/neuropsychiatric measures, and greater association with individual factors such as sex and genetic background. These exploratory findings support inclusion of socio-occupational perspectives in DBS outcome evaluation.