Macroscopic Sertoli cell nodule of the testis containing numerous spermatogonia.

Sertoli cell nodule consists of clusters of seminiferous tubules composed of immature Sertoli cells and, in some cases, spermatogonia. We report a case of macroscopic Sertoli cell nodule that occurred in the descended left testis of a 26-year-old man. The nodule was centrally located and measured 1.7cm in greatest dimension, the largest such lesion reported to date. Spermatogonia were prominent, a feature that is particularly common in the larger nodules. Macroscopic Sertoli cell nodules (greater than 0.5cm) typically occur in a descended testis. The age range of patients in cases reported since the year 2000 is 19-36 years. Unlike incidental Sertoli cell nodules, macroscopic Sertoli cell nodules containing numerous germ cells can be mistaken for several other Sertoli cell and germ cell lesions and neoplasms.