Evaluation of Clinical Outcomes of an Isofocal Optic-Design Intraocular Lens with Double C-Loop Haptics in Eyes with Glaucoma.

Background/

Objectives

To assess the refractive and visual outcomes after implantation of an isofocal optic-design intraocular lens (IOL) with double C-loop haptics following cataract surgery in eyes with primary open-angle glaucoma (POAG).

Methods

This was a prospective, open-label, interventional exploratory study that considered POAG eyes undergoing cataract surgery with implantation of the Isopure Serenity (Beaver-Visitec International, Inc. [BVI], Waltham, MA, USA) IOL. Primary outcomes measured included manifest refraction, monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA) at 80 and 66 cm, uncorrected near visual acuity (UNVA), and distance-corrected near visual acuity (DCNVA) at 40 cm, and photopic binocular defocus curve were evaluated 3 months after surgery.

Results

In total, 22 eyes of 11 patients (nine women, mean age of 68.3 ± 8.3 years) with POAG were enrolled and completed the clinical study. The study found that 100% of the eyes were within ±0.50 D and 86.36% of the eyes showed a postoperative refractive cylinder ≤ 0.25 D. The mean spherical equivalent and refractive cylinder were -0.06 ± 0.30 D and -0.13 ± 0.33 D, respectively. It was also shown that 86.36% and 100% of the eyes had 20/20 or better UDVA and CDVA, respectively. Furthermore, 95.45% and 77.27% of eyes presented a monocular DCIVA value of ≥20/32 at 80 and 66 cm, respectively, and 68.18% of eyes presented a monocular DCNVA value of ≥20/40. The mean monocular CDVA, DCIVA at 80 cm, DCIVA at 66 cm, and DCNVA were -0.09 ± 0.04, 0.12 ± 0.07, 0.21 ± 0.07 and 0.32 ± 0.07 logMAR, respectively. The binocular defocus curve showed good visual acuity at distance and intermediate vision.

Conclusions

The isofocal Isopure Serenity IOL can be implanted in eyes with POAG after cataract surgery, achieving a satisfactory visual performance. Our results suggest that this IOL model is a viable option for selected patients with controlled early/moderate POAG and without central visual field involvement diagnosed with cataracts.