Head & neck · 2026
Changes in Time to Diagnosis of HPV + Oropharyngeal Squamous Cell Carcinoma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Howard Julia, Asad Shaheryar, Gillard Danielle M, Wai Katherine C, Xu Mary Jue, Likhterov Ilya, George Jonathan R, El-Sayed Ivan, Ryan William R, Ha Patrick K, Heaton Chase
Аннотация
BACKGROUND: Timely referral to subspecialty care remains critical for expedited work up and treatment of HPV+ oropharyngeal carcinoma (OPSCC). It is not known if there have been changes in time to diagnosis as the incidence of this disease rises.
METHODS: Retrospective cohort study of 312 patients treated for HPV+ OPSCC at a tertiary referral clinic between 2013 and 2022.
RESULTS: There was a significant difference in time to diagnosis based on year of presentation (p < 0.001). More patients presented with early-stage disease (AJCC 7 Stage I or II) over time (p = 0.002). Presenting symptom (p = 0.021) and patient location ≥ 50 miles from our tertiary referral clinic (p = 0.039) also affected time to diagnosis.
CONCLUSIONS: Time to diagnosis of HPV+ OPSCC changed based on year of presentation, and a higher proportion of patients presented with early-stage disease in more recent years. This may reflect an increased public awareness of HPV+ OPSCC and its symptoms.
METHODS: Retrospective cohort study of 312 patients treated for HPV+ OPSCC at a tertiary referral clinic between 2013 and 2022.
RESULTS: There was a significant difference in time to diagnosis based on year of presentation (p < 0.001). More patients presented with early-stage disease (AJCC 7 Stage I or II) over time (p = 0.002). Presenting symptom (p = 0.021) and patient location ≥ 50 miles from our tertiary referral clinic (p = 0.039) also affected time to diagnosis.
CONCLUSIONS: Time to diagnosis of HPV+ OPSCC changed based on year of presentation, and a higher proportion of patients presented with early-stage disease in more recent years. This may reflect an increased public awareness of HPV+ OPSCC and its symptoms.