[Experimental study on attachment of bacillus Calmette-Guerin to bladder wall with different types of injury].

OBJECTIVE

To investigate whether different types of injury on bladder wall can influence bacillus Calmette-Guerin (BCG) attachment.

METHODS

The bladder mucosa of 24 rabbits were treated by electrocautery,cryocautery and incision on left lateral wall, right lateral wall and posterior wall, respectively. Then radiolabeled BCG ((3)H-BCG) was instilled into bladder. Two hours latter, the injured bladder wall with different methods and non-injured wall (anterior wall of bladder) were surgically removed and digested. The quantity of BCG of each specimen was determined by liquid scintillation counter.

RESULT: The quantity of BCG attachment to bladder wall with different injuries was significantly higher than that of non-injured wall (P<0.001), meanwhile there was no statistically difference among the BCG levels of different injury types (P>0.05).

CONCLUSION

BCG attachment is not influenced by different types of injury on the bladder wall.