AIMS neuroscience · 2026
Phase-specific alpha tACS over the dlPFC does not enhance cognitive reappraisal or autonomic responses: A sham-controlled crossover study.
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Coelho Catarina Gomes, Leite Jorge, Gonzaga Gabriela, Machado Paulo, Carvalho Sandra
Аннотация
BACKGROUND: Cognitive reappraisal (CR) relies on prefrontal top-down control over limbic systems, with the dorsolateral prefrontal cortex (dlPFC) playing a central regulatory role. Alpha-frequency transcranial alternating current stimulation (α-tACS) can modulate cortical oscillations; yet, its causal contribution to emotion regulation (ER) remains unclear.
OBJECTIVE: In this study, we investigated whether in-phase or anti-phase alpha-tACS influenced subjective and physiological responses during cognitive reappraisal of negative emotional stimuli.
METHODS: Forty-two healthy young adults completed three counterbalanced sessions (in-phase, anti-phase, sham) in a single-blind, sham-controlled crossover design. During α-tACS or sham, participants applied three CR strategies (positive, fictional, distancing) while viewing negative and neutral film clips. Valence, arousal, heart rate (HR), skin conductance (SC), respiratory rate (RR), and pre/post-session affect (PANAS) were recorded.
RESULTS: The Emotional Movie Database (EMDB) emotional stimuli elicited the expected subjective and autonomic responses, confirming that the task engaged emotional-reactivity processes. Participants also showed a typical habituation pattern in physiological measures across blocks. However, neither in-phase nor anti-phase alpha-tACS was associated with measurable changes in subjective emotional ratings or autonomic responses relative to sham under the experimental conditions.
CONCLUSION: This study provides the first evaluation of phase-specific alpha-tACS during cognitive reappraisal using film-based stimuli. Under the experimental conditions, no measurable effects of in-phase or anti-phase stimulation on subjective or autonomic measures of ER were observed. Future studies incorporating individualized stimulation frequencies, multi-session protocols, closed-loop stimulation, and concurrent electrophysiological recordings may help clarify the conditions under which phase-specific tACS influences ER.
OBJECTIVE: In this study, we investigated whether in-phase or anti-phase alpha-tACS influenced subjective and physiological responses during cognitive reappraisal of negative emotional stimuli.
METHODS: Forty-two healthy young adults completed three counterbalanced sessions (in-phase, anti-phase, sham) in a single-blind, sham-controlled crossover design. During α-tACS or sham, participants applied three CR strategies (positive, fictional, distancing) while viewing negative and neutral film clips. Valence, arousal, heart rate (HR), skin conductance (SC), respiratory rate (RR), and pre/post-session affect (PANAS) were recorded.
RESULTS: The Emotional Movie Database (EMDB) emotional stimuli elicited the expected subjective and autonomic responses, confirming that the task engaged emotional-reactivity processes. Participants also showed a typical habituation pattern in physiological measures across blocks. However, neither in-phase nor anti-phase alpha-tACS was associated with measurable changes in subjective emotional ratings or autonomic responses relative to sham under the experimental conditions.
CONCLUSION: This study provides the first evaluation of phase-specific alpha-tACS during cognitive reappraisal using film-based stimuli. Under the experimental conditions, no measurable effects of in-phase or anti-phase stimulation on subjective or autonomic measures of ER were observed. Future studies incorporating individualized stimulation frequencies, multi-session protocols, closed-loop stimulation, and concurrent electrophysiological recordings may help clarify the conditions under which phase-specific tACS influences ER.