Inflammopharmacology · 2026
Evaluation of the anti-inflammatory potentials of ethanol leaf extract of Vigna unguiculata in Wistar rats.
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Adegbuyi Adekunle Theophilus, Omoirri Aziakpono Moses, Joseph Oyepata Semeon, Olanlokun John Oludele, Steenkamp Paul Anton
Аннотация
BACKGROUND: Inflammation involves complex biological pathways, notably characterized by the overexpression of cytokines such as IL-1β, TNF-α, IL-6, IL-8, and COX-2. Inflammation is the onset of many diseases and its control will prevent several progression and complications of many diseases.This study investigates the anti-inflammatory activity of ethanol leaf extract of Vigna unguiculata in rat models, with emphasis on its effects on serum inflammatory cytokines and acute-phase reactants.
METHODS: Ethanol extract of Vigna unguiculata leaves was prepared and evaluated for anti-inflammatory activity using carrageenan-induced paw edema and egg albumin-induced paw inflammation models in Wistar rats. Serum levels of IL-1β, TNF-α, IL-6, IL-8, IL-10, IL-13, IFN-γ, CRP, and COX-2 were quantified using ELISA after treatment with extract doses of 100, 200, and 400 mg/kg. Indomethacin (10 mg/kg) served as the standard control. Phytochemical screening and acute toxicity testing were performed.
RESULTS: The extract significantly inhibited paw edema in a dose-dependent manner, with 400 mg/kg showing a 63.2% inhibition at 4 h post-carrageenan injection. Biomarker analysis showed significant decrease of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, CRP, and COX-2) and increase of anti-inflammatory cytokines (IL-10 and IL-13) (p < 0.05 vs. control). No signs of toxicity were observed up to 2000 mg/kg.
CONCLUSION: The anti-inflammatory activity of Vigna unguiculata may be attributed to its modulatory effects on cytokines and acute-phase reactants. This validates its traditional use and suggests potential therapeutic benefits in inflammatory diseases.
METHODS: Ethanol extract of Vigna unguiculata leaves was prepared and evaluated for anti-inflammatory activity using carrageenan-induced paw edema and egg albumin-induced paw inflammation models in Wistar rats. Serum levels of IL-1β, TNF-α, IL-6, IL-8, IL-10, IL-13, IFN-γ, CRP, and COX-2 were quantified using ELISA after treatment with extract doses of 100, 200, and 400 mg/kg. Indomethacin (10 mg/kg) served as the standard control. Phytochemical screening and acute toxicity testing were performed.
RESULTS: The extract significantly inhibited paw edema in a dose-dependent manner, with 400 mg/kg showing a 63.2% inhibition at 4 h post-carrageenan injection. Biomarker analysis showed significant decrease of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, CRP, and COX-2) and increase of anti-inflammatory cytokines (IL-10 and IL-13) (p < 0.05 vs. control). No signs of toxicity were observed up to 2000 mg/kg.
CONCLUSION: The anti-inflammatory activity of Vigna unguiculata may be attributed to its modulatory effects on cytokines and acute-phase reactants. This validates its traditional use and suggests potential therapeutic benefits in inflammatory diseases.