Biomaterial investigations in dentistry · 2026
Redefining regeneration: proposal of a radiographic outcome-based framework for evaluating regenerative endodontic procedures in immature necrotic teeth.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Singhal Ruchi, Bansal Akshita, Chawla Shiwani, Namdev Ritu
Аннотация
PURPOSE: To propose a radiographic classification system for evaluating outcomes of regenerative endodontic procedures (REPs) in immature necrotic permanent teeth.
METHODS: A two-phase retrospective study was conducted. In Phase I, radiographs of 20 cases (2015-2018) were analyzed to identify patterns of apical closure, root lengthening, dentinal wall thickening, intracanal calcification, and periapical healing. Based on these findings, a six-class radiographic classification was proposed:Class 1: Apical closure with increased root length and dentin thickness;Class 2: Apical closure with increased root length only;Class 3: Apical closure with increased dentin thickness only;Class 4: Apical closure without changes in root length or dentin thickness;Class 5: Barrier formation within the canal or coronal to the root end;Class 6: No root dimensional changes with periapical healing of a documented pretreatment periapical radiolucency.In Phase II, the classification was applied to 54 immature single-rooted permanent teeth from 44 patients aged 8-13 years treated with REPs between 2019 and 2023. Baseline and latest available follow-up radiographs were evaluated by two blinded examiners. Reproducibility was assessed using Cohen's kappa, and associations with age and pre-treatment root stage were analyzed using Fisher's exact test.
RESULTS: Class 1 was most frequent. Partial intracanal calcification occurred in 35.18% of cases, with no complete canal obliteration. Age (p = 0.215) and pre-treatment root stage (p = 0.872) were not significantly associated with outcome classes. Inter- and intra-examiner agreement were high (κ = 0.82 and 0.86). All cases were accommodated within the six proposed categories, and no additional outcome classes were observed.
CONCLUSION: This proposed six-class radiographic framework demonstrated good internal reproducibility and may provide a structured basis for outcome reporting after REPs. Prospective multicenter validation is required.
METHODS: A two-phase retrospective study was conducted. In Phase I, radiographs of 20 cases (2015-2018) were analyzed to identify patterns of apical closure, root lengthening, dentinal wall thickening, intracanal calcification, and periapical healing. Based on these findings, a six-class radiographic classification was proposed:Class 1: Apical closure with increased root length and dentin thickness;Class 2: Apical closure with increased root length only;Class 3: Apical closure with increased dentin thickness only;Class 4: Apical closure without changes in root length or dentin thickness;Class 5: Barrier formation within the canal or coronal to the root end;Class 6: No root dimensional changes with periapical healing of a documented pretreatment periapical radiolucency.In Phase II, the classification was applied to 54 immature single-rooted permanent teeth from 44 patients aged 8-13 years treated with REPs between 2019 and 2023. Baseline and latest available follow-up radiographs were evaluated by two blinded examiners. Reproducibility was assessed using Cohen's kappa, and associations with age and pre-treatment root stage were analyzed using Fisher's exact test.
RESULTS: Class 1 was most frequent. Partial intracanal calcification occurred in 35.18% of cases, with no complete canal obliteration. Age (p = 0.215) and pre-treatment root stage (p = 0.872) were not significantly associated with outcome classes. Inter- and intra-examiner agreement were high (κ = 0.82 and 0.86). All cases were accommodated within the six proposed categories, and no additional outcome classes were observed.
CONCLUSION: This proposed six-class radiographic framework demonstrated good internal reproducibility and may provide a structured basis for outcome reporting after REPs. Prospective multicenter validation is required.