Clinica chimica acta; international journal of clinical chemistry · 2026
Technical feasibility and ex vivo validation of a nasogastric tube-integrated potentiometric sensor for continuous intragastric pH monitoring.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Babaloii Fatemeh, Norouzi Parviz, Kianpour Parisa, Borumand Mehrasa Rahimi, Hassani Shokoufeh, Najmeddin Farhad, Rad-Malekshahi Mazda, Mehrpooya Mehdi, Mojtahedzadeh Amirmahdi, Mousavi-Kiasari Seyyed Mohammad Ghasem, Mojtahedzadeh Mojtaba, Javar Hamid Akbari
Аннотация
BACKGROUND: Gastrointestinal dysfunction is a common manifestation of critical illness, yet it is often under-recognized in routine care. In critically ill patients, impaired splanchnic perfusion and stress-mediated physiological responses can cause fluctuating changes in gastric acidity, which may contribute to stress-related mucosal disease (SRMD). Despite the importance of gastric pH in this context, acid-suppressive therapy is generally prescribed empirically, without direct physiological monitoring to guide treatment.
OBJECTIVE & METHODS: To address this clinical blind spot, we developed a standard nasogastric (NG) tube featuring a built-in, miniaturized electrochemical pH sensor. We evaluated its accuracy in simulated gastric fluids across a pH range of 3 to 10. We then validated the device ex-vivo using actual gastric aspirates from intensive care patients, comparing our sensor's readings against standard pH indicator paper.
RESULTS: The integrated sensor demonstrated excellent analytical reliability during laboratory and simulated gastric fluid testing. It provided rapid (∼300 ms) and stable readings for over 24 h under controlled experimental conditions. When tested on the ICU patient samples, the sensor's measurements strongly correlated with traditional pH paper (r ≥ 0.90), showing a mean bias of approximately 0.4 pH units compared with pH indicator paper.
CONCLUSION: Continuous intragastric pH monitoring via a sensor-integrated NG tube is technically feasible and demonstrates acceptable analytical agreement in ex vivo patient samples. This technology provides a foundation for transitioning from empirical treatment to personalized, data-driven acid-suppression strategies in the ICU.
OBJECTIVE & METHODS: To address this clinical blind spot, we developed a standard nasogastric (NG) tube featuring a built-in, miniaturized electrochemical pH sensor. We evaluated its accuracy in simulated gastric fluids across a pH range of 3 to 10. We then validated the device ex-vivo using actual gastric aspirates from intensive care patients, comparing our sensor's readings against standard pH indicator paper.
RESULTS: The integrated sensor demonstrated excellent analytical reliability during laboratory and simulated gastric fluid testing. It provided rapid (∼300 ms) and stable readings for over 24 h under controlled experimental conditions. When tested on the ICU patient samples, the sensor's measurements strongly correlated with traditional pH paper (r ≥ 0.90), showing a mean bias of approximately 0.4 pH units compared with pH indicator paper.
CONCLUSION: Continuous intragastric pH monitoring via a sensor-integrated NG tube is technically feasible and demonstrates acceptable analytical agreement in ex vivo patient samples. This technology provides a foundation for transitioning from empirical treatment to personalized, data-driven acid-suppression strategies in the ICU.