F&S science · 2026
The effects of microplastics on sperm motility: an in vitro experimental study.
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Jain Meaghan, Lopez Ashanta, Jacobs Alva, Jindal Sangita, Davies Kelvin
Аннотация
OBJECTIVE: Although microplastics such as polyethylene (PE) and polystyrene (PS) have been identified in human semen, their clinical impact is still under investigation; this study evaluates the in vitro effect of PE and PS microplastics on sperm motility parameters and deoxyribonucleic acid fragmentation in human semen samples.
DESIGN: Experimental study.
SUBJECTS: Postejaculate semen samples from men evaluated at a New York fertility center (October 2024-September 2025) were collected. Samples with normal sperm concentration and morphology were included; those with baseline total motility below 2% were excluded.
EXPOSURE: Each sample was divided into 200 μL aliquots and exposed to 0 (control), 1, 2, 4, 8, or 16 μL of 10% PE (34-50 μm) or PS (10 μm) microbead solutions and incubated for 2 hours at 20°C-22°C.
MAIN OUTCOME MEASURES: Total motility, progressive motility, average path velocity (VAP), curvilinear velocity (VCL), straight-line velocity (VSL) RESULTS: Thirty-two semen samples were analyzed for motility changes. Within each exposure group, 20 samples had normal baseline motility and 10 had low baseline motility according to World Health Organization 5th edition criteria. Exposure to both PS and PE in both groups resulted in a dose-dependent reduction of greater than 10% in VAP and VSL from baseline compared with controls. Total and progressive motility were not significantly impacted.
CONCLUSION: In vitro exposure to PS and PE microplastics significantly impaired sperm kinematic parameters (VAP, VCL, and VSL) without affecting overall motility. These findings raise concern about environmental exposure and support the need for further research on their reproductive impact.
DESIGN: Experimental study.
SUBJECTS: Postejaculate semen samples from men evaluated at a New York fertility center (October 2024-September 2025) were collected. Samples with normal sperm concentration and morphology were included; those with baseline total motility below 2% were excluded.
EXPOSURE: Each sample was divided into 200 μL aliquots and exposed to 0 (control), 1, 2, 4, 8, or 16 μL of 10% PE (34-50 μm) or PS (10 μm) microbead solutions and incubated for 2 hours at 20°C-22°C.
MAIN OUTCOME MEASURES: Total motility, progressive motility, average path velocity (VAP), curvilinear velocity (VCL), straight-line velocity (VSL) RESULTS: Thirty-two semen samples were analyzed for motility changes. Within each exposure group, 20 samples had normal baseline motility and 10 had low baseline motility according to World Health Organization 5th edition criteria. Exposure to both PS and PE in both groups resulted in a dose-dependent reduction of greater than 10% in VAP and VSL from baseline compared with controls. Total and progressive motility were not significantly impacted.
CONCLUSION: In vitro exposure to PS and PE microplastics significantly impaired sperm kinematic parameters (VAP, VCL, and VSL) without affecting overall motility. These findings raise concern about environmental exposure and support the need for further research on their reproductive impact.