Neurodegenerative disease management · 2026
Burden of Parkinson's disease from 1990 to 2021 at the global, regional, and national level, with forecasts to 2035.
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Huang Sibo, Wu Jialin, Chen Gerun, Liang Yuefei, Chen Zhiguo, Xia Jun, He Wenjie
Аннотация
BACKGROUND: Parkinson's disease (PD) poses a growing global health challenge. Our study systematically assessed the global, regional, and national burden of PD from 1990 to 2021 and projected trends to 2035.
METHODS: This study utilized data from the Global Burden of Disease (GBD) 2021 to systematically analyze the global, burden of PD from 1990 to 2021 and project trends up to 2035. By integrating prevalence, mortality, and disability-adjusted life years (DALY) metrics, alongside Socio-Demographic Index (SDI), we employed the Bayesian age-period-cohort (BAPC) model and decomposition analysis to assess drivers of PD burden.
RESULTS: From 1990 to 2021, the prevalence of PD increased by 273.75%, mortality increased by 162.17%. In terms of regions, the low-middle SDI regions had the highest average annual percentage changes (EAPC) in prevalence, mortality, which were 4.57%, 2.51%, respectively. Projections from 2022 to 2035 suggest that the prevalence will continue to rise, while mortality is expected to decline.
CONCLUSIONS: The global burden of PD exhibits a persistent upward trajectory. This is particularly noticeable among middle-aged and elderly men, as well as in regions with the low-middle SDI. Targeted measures to address regional healthcare gaps and to improve global aging are crucial for mitigating the burden of PD.
METHODS: This study utilized data from the Global Burden of Disease (GBD) 2021 to systematically analyze the global, burden of PD from 1990 to 2021 and project trends up to 2035. By integrating prevalence, mortality, and disability-adjusted life years (DALY) metrics, alongside Socio-Demographic Index (SDI), we employed the Bayesian age-period-cohort (BAPC) model and decomposition analysis to assess drivers of PD burden.
RESULTS: From 1990 to 2021, the prevalence of PD increased by 273.75%, mortality increased by 162.17%. In terms of regions, the low-middle SDI regions had the highest average annual percentage changes (EAPC) in prevalence, mortality, which were 4.57%, 2.51%, respectively. Projections from 2022 to 2035 suggest that the prevalence will continue to rise, while mortality is expected to decline.
CONCLUSIONS: The global burden of PD exhibits a persistent upward trajectory. This is particularly noticeable among middle-aged and elderly men, as well as in regions with the low-middle SDI. Targeted measures to address regional healthcare gaps and to improve global aging are crucial for mitigating the burden of PD.