DJ-1 (PARK7) as a Redox-Responsive Integrator of Pancreatic, Hepatic, and Adipose Crosstalk in Glucose Homeostasis.

DJ-1 (PARK7), originally characterized in Parkinson's disease, is increasingly recognized as a redox-sensitive regulator of systemic metabolism. Acting through oxidation-dependent modulation of Cys106, DJ-1 integrates cellular redox cues with mitochondrial function, insulin signaling, and stress adaptation pathways. In pancreatic β-cells, it preserves stimulus secretion coupling by stabilizing mitochondrial ATP production. In liver and adipose tissue, DJ-1 maintains insulin responsive signaling and metabolic flexibility through PTEN-PI3K-Akt and antioxidant networks. Loss or over-oxidation of DJ-1 disrupts interorgan glucose coordination, linking chronic redox imbalance to dysglycemia. This review positions DJ-1 as a metabolic sentinel translating oxidative inputs into integrated glucose regulatory outputs.