Taiwan journal of ophthalmology · 2026
Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence tomography angiography: A pilot study.
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Huang Yao-Chi, Chuang Lan-Hsin, Yeung Ling, Chen Hung-Chi, Tsai Tsung-Hsien, Wang Nan-Kai, Chang Po-Chun, Hwang Yih-Shiou, Wu Wei-Chi, Lai Chi-Chun, Liu Chun-Fu
Аннотация
PURPOSE: The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retinal microvascular changes and the effects of myopia treatment.
MATERIALS AND METHODS: This is a prospective cohort study. Children with myopia aged 5-18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL).
RESULTS: A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (P = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = -0.430, P = 0.028).
CONCLUSION: These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.
MATERIALS AND METHODS: This is a prospective cohort study. Children with myopia aged 5-18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL).
RESULTS: A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (P = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = -0.430, P = 0.028).
CONCLUSION: These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.