The Journal of nutrition · 2026
Insulin Resistance Mediates Associations of Weight Gain with Serum Uric Acid and Hyperuricemia in Chinese Population.
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Huang Shanshan, Wen Junxin, Qin Qingxin, Liang Yanyu, Meng Fanli
Аннотация
BACKGROUND: Studies on the association between weight change and serum uric acid (SUA) or hyperuricemia (HUA) remain limited, and the underlying mechanisms remain unclear.
OBJECTIVES: This study aimed to explore the relationships between weight change and SUA or HUA among Chinese adults, and to assess the mediating role of insulin resistance (IR).
METHODS: We analyzed data from participants who underwent ≥2 annual health examinations between January 2015 and May 2025. Weight change (%) was calculated as (follow-up value - baseline value)/baseline value. Generalized linear models and logistic regression were used to examine the associations of weight change with SUA and HUA, whereas mediation analysis was applied to evaluate the mediating effects of IR indices.
RESULTS: A total of 16,688 eligible participants were included, with 15.0% having HUA. The median follow-up duration was 2.00 (1.00, 4.00) years. Each 1-standard deviation increase in weight change was associated with a 10.48 μmol/L increase in SUA and a 30.0% higher risk of HUA. Atherogenic index of plasma, triglyceride-glucose index, triglyceride-glucose body mass index, and the metabolic score for insulin resistance were positively linearly associated with SUA and HUA. All 4 IR indices partially mediated the associations of weight change with SUA concentrations and HUA risk. Compared with individuals with stable weight, the weight-loss group had a significantly lower HUA risk, whereas the weight-gain group had a 78% higher HUA risk.
CONCLUSIONS: Weight gain was associated with elevated SUA concentrations and increased HUA risk, and insulin resistance may be one of the underlying mechanisms.
OBJECTIVES: This study aimed to explore the relationships between weight change and SUA or HUA among Chinese adults, and to assess the mediating role of insulin resistance (IR).
METHODS: We analyzed data from participants who underwent ≥2 annual health examinations between January 2015 and May 2025. Weight change (%) was calculated as (follow-up value - baseline value)/baseline value. Generalized linear models and logistic regression were used to examine the associations of weight change with SUA and HUA, whereas mediation analysis was applied to evaluate the mediating effects of IR indices.
RESULTS: A total of 16,688 eligible participants were included, with 15.0% having HUA. The median follow-up duration was 2.00 (1.00, 4.00) years. Each 1-standard deviation increase in weight change was associated with a 10.48 μmol/L increase in SUA and a 30.0% higher risk of HUA. Atherogenic index of plasma, triglyceride-glucose index, triglyceride-glucose body mass index, and the metabolic score for insulin resistance were positively linearly associated with SUA and HUA. All 4 IR indices partially mediated the associations of weight change with SUA concentrations and HUA risk. Compared with individuals with stable weight, the weight-loss group had a significantly lower HUA risk, whereas the weight-gain group had a 78% higher HUA risk.
CONCLUSIONS: Weight gain was associated with elevated SUA concentrations and increased HUA risk, and insulin resistance may be one of the underlying mechanisms.