Photodiagnosis and photodynamic therapy · 2026
Biomarkers for detecting and predicting macular neovascularization in age-related macular degeneration using optical coherence tomography angiography: a systematic review.
Систематический обзорСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pourbagherkhah Parva, Baghban Jaldian Hemn
Аннотация
PURPOSE: This systematic review evaluates the role of optical coherence tomography angiography (OCTA)-based biomarkers in detecting and predicting macular neovascularization (MNV) in age-related macular degeneration (ARMD).
METHODS: A comprehensive literature search was conducted in PubMed, Web of Science, Scopus and Google Scholar up to 20 May 2026, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria encompassed original cohort and cross-sectional studies reporting OCTA-derived quantitative and qualitative biomarkers associated with MNV.
RESULTS: A total of 203 articles were initially identified, with 11 studies meeting the eligibility criteria, comprising 642 eyes. Key OCTA biomarkers included vascular density, MNV area, total vessel length, and choroidal vascularity index, which demonstrated strong associations with disease activity and progression.
CONCLUSION: OCTA-derived biomarkers offer a non-invasive and effective means for detecting and monitoring MNV in ARMD. Despite current challenges in standardization and interpretation, integrating these biomarkers into clinical practice could improve early diagnosis and personalized treatment strategies.
METHODS: A comprehensive literature search was conducted in PubMed, Web of Science, Scopus and Google Scholar up to 20 May 2026, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria encompassed original cohort and cross-sectional studies reporting OCTA-derived quantitative and qualitative biomarkers associated with MNV.
RESULTS: A total of 203 articles were initially identified, with 11 studies meeting the eligibility criteria, comprising 642 eyes. Key OCTA biomarkers included vascular density, MNV area, total vessel length, and choroidal vascularity index, which demonstrated strong associations with disease activity and progression.
CONCLUSION: OCTA-derived biomarkers offer a non-invasive and effective means for detecting and monitoring MNV in ARMD. Despite current challenges in standardization and interpretation, integrating these biomarkers into clinical practice could improve early diagnosis and personalized treatment strategies.