Lasers in surgery and medicine · 2026
Wavefront Shaping for Deep-Tissue Therapeutic Light Delivery: From Optical Focusing to Precision Photomedicine.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wu Ziyi, Li Jinze, Fei Duheng, Dong Xiaoxi, Dai Jianwu, Yin Huijuan
Аннотация
OBJECTIVES: To systematically evaluate wavefront shaping (WFS) as a strategy for deep-tissue phototherapy, assessing progress and translational readiness across four clinically relevant dimensions.
METHODS: Narrative review of three mainstream WFS strategies-feedback iterative optimization, transmission matrix (TM) measurement, and optical phase conjugation (OPC)-evaluated against the core requirements of phototherapy: penetration depth, energy deposition accuracy, dynamic stability, and clinical translation.
RESULTS: Time-reversal of ultrasound-encoded (TRUE)-based WFS has achieved TRUE-based WFS has demonstrated focusing through approximately 2 mm of living brain tissue, substantially exceeding the approximately 1 mm limit of conventional optics. Peak-to-background ratios (PBR) exceeding 400 have been demonstrated with natural gradient optimization algorithms, and millisecond-scale system response times have been achieved with digital optical phase conjugation. However, no study has simultaneously demonstrated millisecond-scale correction and sustained, therapeutically effective, and safe light-dose delivery in a living model, and only one study has established a quantitative relationship between WFS optical optimization and a biophysical therapeutic endpoint.
CONCLUSIONS: WFS demonstrates compelling optical capabilities that directly address the physical barriers limiting conventional phototherapy. Clinical translation requires a shift from optical demonstration to therapeutic validation, incorporating standardized preclinical protocols, absolute light-dose measurement at the target, and multidimensional biological endpoint assessment.
METHODS: Narrative review of three mainstream WFS strategies-feedback iterative optimization, transmission matrix (TM) measurement, and optical phase conjugation (OPC)-evaluated against the core requirements of phototherapy: penetration depth, energy deposition accuracy, dynamic stability, and clinical translation.
RESULTS: Time-reversal of ultrasound-encoded (TRUE)-based WFS has achieved TRUE-based WFS has demonstrated focusing through approximately 2 mm of living brain tissue, substantially exceeding the approximately 1 mm limit of conventional optics. Peak-to-background ratios (PBR) exceeding 400 have been demonstrated with natural gradient optimization algorithms, and millisecond-scale system response times have been achieved with digital optical phase conjugation. However, no study has simultaneously demonstrated millisecond-scale correction and sustained, therapeutically effective, and safe light-dose delivery in a living model, and only one study has established a quantitative relationship between WFS optical optimization and a biophysical therapeutic endpoint.
CONCLUSIONS: WFS demonstrates compelling optical capabilities that directly address the physical barriers limiting conventional phototherapy. Clinical translation requires a shift from optical demonstration to therapeutic validation, incorporating standardized preclinical protocols, absolute light-dose measurement at the target, and multidimensional biological endpoint assessment.