Clinical parkinsonism & related disorders · 2025
Cognition is associated with daily-life mobility in people with Parkinson's disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Burgos Pablo I, Silva-Batista Carla, Ragothaman Anjanibhargavi, Shah Vrutangkumar V, Carlson-Kuhta Patricia, Horak Fay B, Mancini Martina
Аннотация
INTRODUCTION: Cognitive impairment is common in people with Parkinson's disease (PD). Mobility is also impaired in people with PD and functional mobility often requires cognitive dual-tasking to navigate complex environments in daily life. We hypothesized that visuospatial and executive cognitive dysfunction in people with PD will be associated with digital measures of mobility in daily life. Since freezing of gait (FoG) is associated with both cognitive dysfunction and mobility impairments, we also examined the influence of FoG on the cognition-mobility relationship. Here, we investigated, for the first time, the association between cognition and daily-life mobility in PD and the influence of FoG status.
METHODS: 60 individuals with mild-to-moderate PD (17 with FoG and 43 without FoG) wore 3 inertial sensors (lumbar and feet) for a week of passive monitoring of mobility. Digital visuospatial (Line Orientation task) and executive tasks (Set-Shifting and Flanker task) were assessed in the ON medication state.
RESULTS: Visuospatial function was significantly associated with gait speed (r = -0.46, p = 0.008) and stride length (r = -0.40, p = 0.022). Set Shifting was significantly associated with stance time (r = -0.35, p = 0.046), double support time (r = -0.35, p = 0.046), and the variability of step duration during turning (r = 0.44, p = 0.016). The Flanker test was not associated with any gait variables. FoG status was less important than disease duration or age in the cognitive-mobility associations.
CONCLUSIONS: Specific types of cognition were related to specific gait variables in daily life. People with PD with worse visuospatial functions had worse gait pace. In contrast, participants with worse executive function (set-switching) had worse dynamic postural control during gait. FoG status showed minimal influence on these associations.
METHODS: 60 individuals with mild-to-moderate PD (17 with FoG and 43 without FoG) wore 3 inertial sensors (lumbar and feet) for a week of passive monitoring of mobility. Digital visuospatial (Line Orientation task) and executive tasks (Set-Shifting and Flanker task) were assessed in the ON medication state.
RESULTS: Visuospatial function was significantly associated with gait speed (r = -0.46, p = 0.008) and stride length (r = -0.40, p = 0.022). Set Shifting was significantly associated with stance time (r = -0.35, p = 0.046), double support time (r = -0.35, p = 0.046), and the variability of step duration during turning (r = 0.44, p = 0.016). The Flanker test was not associated with any gait variables. FoG status was less important than disease duration or age in the cognitive-mobility associations.
CONCLUSIONS: Specific types of cognition were related to specific gait variables in daily life. People with PD with worse visuospatial functions had worse gait pace. In contrast, participants with worse executive function (set-switching) had worse dynamic postural control during gait. FoG status showed minimal influence on these associations.