Leveraging the Barriers and Facilitators of Pre-exposure Prophylaxis (PrEP) Care Among Latino Men Who Have Sex with Men in the U.S. to Inform Intervention: A Systematic Literature Review (2018-2023).

HIV disproportionately affects Latino men who have sex with men (LMSM) in the United States (U.S.). Pre-exposure prophylaxis (PrEP) reduces HIV transmission, but prescription and use rates remain low among this population. This systematic literature review aimed to (1) identify and categorize barriers and facilitators of LMSM's PrEP use, and (2) leverage findings for future interventions. The PICOS structure was used to establish inclusion criteria to search studies published between 2018 and 2023 on December 24 2023. Covidence was used to screen studies and PRISMA 2020 to report the findings. Barriers/facilitators were categorized across the PrEP continuum of care and domains of the WHO 2024 Operational framework. Most barriers and facilitators were related to PrEP information/knowledge, provider influences, PrEP/insurance costs, immigration status, and government/medical mistrust. Findings highlight the need for culturally adapted/tailored PrEP interventions that leverage LMSM social networks, incorporate accessible PrEP service delivery, address language barriers, and involve community-based PrEP navigators.