Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
Relative Incidence of Multiple Primary Cancers in Male World Trade Center Responders: A Comparison with SEER.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Turner Wiley M, Joyama Yuki, Dasaro Christopher R, Todd Andrew C, Tuminello Stephanie, Taioli Emanuela
Аннотация
BACKGROUND: World Trade Center (WTC) responders were exposed to carcinogens during rescue, recovery, and cleanup operations following September 11, 2001. Although responders have an elevated risk of various primary cancers, they may also have an increased risk of second primary cancers. This study evaluates the incidence of multiple primary cancers among male responders compared with a population-based cohort.
METHODS: We assembled a cohort of male WTC general responders with cancer diagnosed between 2002 and 2022 and compared them with male patients with cancer from Surveillance, Epidemiology, and End Results (SEER) diagnosed during the same period. Crude and age-standardized proportion ratios (PR) were used to compare the occurrence of multiple primary cancers between cohorts.
RESULTS: Among 4,815 WTC responders, we observed a higher age-standardized proportion of multiple primary cancers than among 3,376,402 SEER patients [PR = 1.84; 95% confidence interval (CI), 1.61-2.11]. The proportion of multiple primary cancers was higher among younger WTC responders than SEER patients (20-44 years: PR = 3.76; 95% CI, 3.04-4.67; 45-54 years: PR = 1.36; 95% CI, 1.17-1.58), whereas responders aged 65+ had lower proportions (PR = 0.79; 95% CI, 0.65-0.96).
CONCLUSIONS: Male WTC responders experience a higher burden of multiple primary cancers than the general US population, particularly at younger ages, highlighting multiple primary cancers as an underrecognized consequence of WTC exposure.
IMPACT: Enhanced cancer monitoring strategies may be warranted for WTC responders and other populations that have been similarly exposed. See related In the Spotlight, p. 1683.
METHODS: We assembled a cohort of male WTC general responders with cancer diagnosed between 2002 and 2022 and compared them with male patients with cancer from Surveillance, Epidemiology, and End Results (SEER) diagnosed during the same period. Crude and age-standardized proportion ratios (PR) were used to compare the occurrence of multiple primary cancers between cohorts.
RESULTS: Among 4,815 WTC responders, we observed a higher age-standardized proportion of multiple primary cancers than among 3,376,402 SEER patients [PR = 1.84; 95% confidence interval (CI), 1.61-2.11]. The proportion of multiple primary cancers was higher among younger WTC responders than SEER patients (20-44 years: PR = 3.76; 95% CI, 3.04-4.67; 45-54 years: PR = 1.36; 95% CI, 1.17-1.58), whereas responders aged 65+ had lower proportions (PR = 0.79; 95% CI, 0.65-0.96).
CONCLUSIONS: Male WTC responders experience a higher burden of multiple primary cancers than the general US population, particularly at younger ages, highlighting multiple primary cancers as an underrecognized consequence of WTC exposure.
IMPACT: Enhanced cancer monitoring strategies may be warranted for WTC responders and other populations that have been similarly exposed. See related In the Spotlight, p. 1683.