Active Noise Cancellation in Ultra-Low Field MRI: Distinct Strategies for Different Channels.

Ultra-low field magnetic resonance imaging (ULF-MRI) systems operating in open environments are highly susceptible to composite electromagnetic interference (EMI). Different imaging channels respond non-uniformly to EMI owing to their distinct coupling characteristics. Here, we investigate channel-specific interference pathways in a permanent-magnet-based low-field MRI system and show that saddle coils are intrinsically more vulnerable to transverse EMI components than solenoidal coils. To mitigate these heterogeneous coupling effects, we propose a dual-stage suppression strategy that combines front-end spatial-domain inverse field reconstruction with back-end channel-adaptive active noise cancellation. Experiments demonstrate that this approach suppresses EMI by more than 80%, substantially improves inter-channel signal-to-noise ratio (SNR) consistency, and enhances the fused-image SNR by ~24%. These findings elucidate the channel-dependent nature of EMI coupling and establish targeted mitigation strategies, providing both a theoretical basis and practical guidance for noise suppression in future array-coil ULF-MRI systems.