[Interaction of gastrointestinal peptides and the autonomic nervous system in the contractile function of the gallbladder].

Within 15 to 30 days after right unilateral subdiaphragmal vagotomy, resection of the anterior liver nervous plexus and mucosoantrumectomy in dogs, the gall bladder contractile function weakens and its adsorbing and concentrating functions are considerably impaired. Within a year these disturbances become less obvious and tend to normalize. These disturbances prove the local hormonal and the autonomic neural control in the gall excreting system. In the digestion phase, neurotensin, angiotensin and enkephalin inhibited the gall bladder motility. This effect was facilitated after sympathectomy and vagotomy due to non-adrenergic inhibitory influences on the gall bladder. Enkephalin might be capable of a direct effect upon the smooth muscles, particularly upon the muscle fibers of the gall bladder's neck. Pentagastrin was found to exert a biphasic effect on the Oddi sphincter tone: exciting the sphincter's circular muscles and inhibiting them with non-cholinergic and non-adrenergic neurons.