Awareness, Willingness, and Use of Doxycycline Post-Exposure Prophylaxis Among Men Who Have Sex with Men in Taiwan.

Doxycycline post-exposure prophylaxis (doxyPEP) engagement-awareness, willingness, and use-for bacterial sexually transmitted infection (STI) prevention remains understudied in Taiwan. This secondary analysis used logistic regression to examine doxyPEP engagement and its correlates among 1,654 men who have sex with men (MSM) in Taiwan (November-December 2023). Awareness, willingness, and use were reported by 24.4%, 33.0%, and 2.9% of participants, respectively. Awareness, willingness, and use were greater among MSM not living with HIV and taking PrEP and MSM living with HIV than among MSM not living with HIV and not taking PrEP. Bacterial STI diagnosis was associated with greater willingness and use; age ≥ 40 years, condomless anal sex, and receipt of ≥ 1 mpox vaccine dose were also associated with greater willingness. These findings suggest that PrEP and HIV treatment services and bacterial STI screening and treatment encounters may offer opportunities for doxyPEP delivery, while additional strategies may be needed to reach MSM not routinely engaged in these services.