BMJ open · 2026
Objective data-driven personalised approach to diagnosis of chronic tinnitus: the Tinnitus Detection (TIDE) project - protocol for the identification and validation of a biomarker for tinnitus.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Vanneste Sven, Yasoda-Mohan Anusha, Chen Feifan, Arulchelvan Elva, Shields Nathan, Braun Christoph, Campbell Julia, De Ridder Dirk, Engelke Milena, Fink Stefan, Husain Fatima T, Jain Namitha, Kleinjung Tobias, Kim Gibbeum, Knipper Marlies, Langguth Berthold, Lu Hongyu, Neff Patrick, Ralston Lauren, Riegger Elinor, Rüttiger Lukas, Schlee Winfried, Tödtli Beat, Shabestari Payam S, Ajmera Shagun, Staudinger Susanne, Wolpert Stephan, Cederroth Christopher R
Аннотация
BACKGROUND: Tinnitus is the perception of sound without an external source, often considered a phantom percept similar to phantom limb sensations, resulting from maladaptive plasticity in the brain. The condition lacks an established biomarker for diagnosis but recent studies have linked it to neural changes. The Tinnitus Detection consortium aims to identify and validate potential biomarkers for tinnitus presence and intensity.
METHODS/DESIGN: This multicentre prospective case-control study will recruit 560 adults (280 chronic tinnitus; 280 controls). Participants will complete standardised audiological and questionnaire assessments and then undergo 64-channel electroencephalography (and magnetoencephalography at one site) to record event-related potentials during (1) a cortical gap prepulse inhibition of the acoustic startle (GPIAS) paradigm assessing gap-related inhibition of the N1 response and (2) an omission auditory oddball paradigm quantifying mismatch negativity and P300 as candidate biomarkers of tinnitus presence and loudness.
DISCUSSION: The identification of a biomarker for tinnitus is crucial for developing personalised diagnosis and treatment: There is a need for updated guidelines and more effective tinnitus treatments, as existing interventions often rely on subjective measures. The success of biomarkers like GPIAS and oddball paradigms could significantly improve the reliability of tinnitus diagnosis and treatment, marking a transformative step in the field.
TRIAL REGISTRATION NUMBER: NCT06520865.
METHODS/DESIGN: This multicentre prospective case-control study will recruit 560 adults (280 chronic tinnitus; 280 controls). Participants will complete standardised audiological and questionnaire assessments and then undergo 64-channel electroencephalography (and magnetoencephalography at one site) to record event-related potentials during (1) a cortical gap prepulse inhibition of the acoustic startle (GPIAS) paradigm assessing gap-related inhibition of the N1 response and (2) an omission auditory oddball paradigm quantifying mismatch negativity and P300 as candidate biomarkers of tinnitus presence and loudness.
DISCUSSION: The identification of a biomarker for tinnitus is crucial for developing personalised diagnosis and treatment: There is a need for updated guidelines and more effective tinnitus treatments, as existing interventions often rely on subjective measures. The success of biomarkers like GPIAS and oddball paradigms could significantly improve the reliability of tinnitus diagnosis and treatment, marking a transformative step in the field.
TRIAL REGISTRATION NUMBER: NCT06520865.