Plexiform neurofibroma of the scrotum in a 16-year-old male: A case report.

Plexiform neurofibroma is a benign peripheral nerve sheath tumor considered pathognomonic for neurofibromatosis type 1. Isolated scrotal occurrence without systemic manifestations of neurofibromatosis type 1 is exceedingly rare. We report a 16-year-old male with a progressively enlarging right scrotal mass measuring 8 × 4 cm. There were no café-au-lait spots, axillary freckling, or family history of neurofibromatosis type 1. Magnetic resonance imaging showed the characteristic target sign. Complete surgical excision via a scrotal approach with testicular preservation was performed. Histopathology confirmed plexiform neurofibroma, with positive staining for S-100, SOX10, and CD34. No recurrence was observed at 6-month follow-up.