Voices: Emerging molecular mechanisms and open questions in post-translational modifications.

Post-translational modifications expand the functional diversity of the proteome and provide dynamic control over protein activity, localization, interactions, and stability, making them fundamental regulators of cellular function. In this Voices piece accompanying a special issue on post-translational modifications in Cell Chemical Biology, we ask researchers from across the field: what recent advances in post-translational modification research are most exciting, what important challenges remain, and what are the next big questions for the field?