Infection · 2026
Short-course versus long-course antibiotics in bone infections: a meta-analysis of randomised controlled trials.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Yang, Sun Yu, Feng Zhaolun, Hakert Bo, Ma Jiantong, Cornish Jillian
Аннотация
PURPOSE: The optimal duration of antibiotic therapy for bone infections remains controversial. We therefore conducted a meta-analysis of randomised controlled trials (RCTs) comparing short- versus long-course antibiotic therapy for bone infections.
METHODS: PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were searched through February 2026 for RCTs comparing short- and long-course antibiotic therapy in bone infections, including periprosthetic joint infection, diabetic foot osteomyelitis, vertebral osteomyelitis, and paediatric acute haematogenous osteomyelitis. Treatment failure and antibiotic-related adverse events were analysed using both intention-to-treat (ITT) and per-protocol (PP) data. Risk of bias and certainty of evidence were assessed using ROB 1 and GRADE.
RESULTS: In the ITT analysis, no significant difference in treatment failure was observed between short- and long-course therapy (RR = 1.12, 95% CI 0.77-1.62, P = 0.55). The PP analysis suggested a potential increase in treatment failure with short-course therapy (RR = 1.47, 95% CI 1.00-2.16, P = 0.05). Short-course therapy was associated with a significantly lower risk of antibiotic-related adverse events (RR = 0.81, 95% CI 0.69-0.94, P = 0.006). Certainty of evidence was moderate for treatment failure outcomes and high for adverse events.
CONCLUSION: No statistically significant difference in treatment failure was observed between short- and long-course antibiotic therapy in the ITT analysis, whereas short-course therapy was associated with significantly fewer antibiotic-related adverse events. However, the PP analysis suggested a possible increase in treatment failure with short-course therapy. The included bone infections were clinically heterogeneous, which may limit generalisability.
METHODS: PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were searched through February 2026 for RCTs comparing short- and long-course antibiotic therapy in bone infections, including periprosthetic joint infection, diabetic foot osteomyelitis, vertebral osteomyelitis, and paediatric acute haematogenous osteomyelitis. Treatment failure and antibiotic-related adverse events were analysed using both intention-to-treat (ITT) and per-protocol (PP) data. Risk of bias and certainty of evidence were assessed using ROB 1 and GRADE.
RESULTS: In the ITT analysis, no significant difference in treatment failure was observed between short- and long-course therapy (RR = 1.12, 95% CI 0.77-1.62, P = 0.55). The PP analysis suggested a potential increase in treatment failure with short-course therapy (RR = 1.47, 95% CI 1.00-2.16, P = 0.05). Short-course therapy was associated with a significantly lower risk of antibiotic-related adverse events (RR = 0.81, 95% CI 0.69-0.94, P = 0.006). Certainty of evidence was moderate for treatment failure outcomes and high for adverse events.
CONCLUSION: No statistically significant difference in treatment failure was observed between short- and long-course antibiotic therapy in the ITT analysis, whereas short-course therapy was associated with significantly fewer antibiotic-related adverse events. However, the PP analysis suggested a possible increase in treatment failure with short-course therapy. The included bone infections were clinically heterogeneous, which may limit generalisability.