Comment on "High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence".

Godinho et al. reported that high-intensity interval training (HIIT) modulated molecular and cellular markers associated with neuroprotection in a β-amyloid-induced model of Alzheimer's disease. However, the causal relationship between reduced APP expression and neuronal apoptosis, the translation of molecular adaptations into cognitive outcomes, and the discrepancy between FNDC5 mRNA and protein expression remain unclear. This Letter highlights these three considerations and discusses potential mechanisms that warrant further investigation.