Case reports in dentistry · 2026
A Lip Mass Revealing Syphilis: A Case Report With a Review of the Literature.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alsenani May Ahmed, Alshagroud Rana Saud, Hadlaq Emad, Aldawsari Bader Mutrik, Khormi Hassan Ibrahim, Altariqi Abdulrahman A, Aloushan Norah Ameen, Aloshaywi Abdulaziz Khalid, Alangari Mohammed Abdulaziz
Аннотация
BACKGROUND: Syphilis is a chronic systemic infection caused by Treponema pallidum and is well known for its wide spectrum of clinical presentations. Oral manifestations are uncommon and often mimic benign or reactive lesions, making diagnosis challenging, particularly in the absence of overt systemic symptoms.
CASE PRESENTATION: We report a case of a 26-year-old male who presented with a nonpainful swelling of the lower lip that had persisted for 2 months, with a differential diagnosis including both reactive and neoplastic processes, and underwent a biopsy for definitive diagnosis. Histopathological examination demonstrated ulcerated oral mucosa with psoriasiform epithelial hyperplasia, neutrophilic transmigration, and a dense chronic inflammatory infiltrate rich in plasma cells. Immunohistochemical staining highlighted Treponema pallidum organisms within the lesional tissue, and serologic testing was positive, confirming the diagnosis of syphilis. At follow-up, the patient developed additional oral ulcers and a maculopapular rash involving the palms, soles, and genitalia, consistent with systemic disease, and was referred for medical management.
CONCLUSION: This case underscores the importance of considering syphilis in the differential diagnosis of atypical oral lesions. Early recognition by dental practitioners, supported by histopathological evaluation, immunohistochemistry, and serologic testing, is essential for timely diagnosis, appropriate referral, and prevention of disease progression and transmission.
CASE PRESENTATION: We report a case of a 26-year-old male who presented with a nonpainful swelling of the lower lip that had persisted for 2 months, with a differential diagnosis including both reactive and neoplastic processes, and underwent a biopsy for definitive diagnosis. Histopathological examination demonstrated ulcerated oral mucosa with psoriasiform epithelial hyperplasia, neutrophilic transmigration, and a dense chronic inflammatory infiltrate rich in plasma cells. Immunohistochemical staining highlighted Treponema pallidum organisms within the lesional tissue, and serologic testing was positive, confirming the diagnosis of syphilis. At follow-up, the patient developed additional oral ulcers and a maculopapular rash involving the palms, soles, and genitalia, consistent with systemic disease, and was referred for medical management.
CONCLUSION: This case underscores the importance of considering syphilis in the differential diagnosis of atypical oral lesions. Early recognition by dental practitioners, supported by histopathological evaluation, immunohistochemistry, and serologic testing, is essential for timely diagnosis, appropriate referral, and prevention of disease progression and transmission.