Addiction & health · 2026
Marijuana (Cannabis) Smoking Increases the Risk of Lung Cancer: Evidence from a Systematic Review and Meta-Analysis.
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Karimi Mehdi, Kazemi Kimia, Pourhanifeh Mohammad Hossein, Irajian Parsa, Asbaghi Omid
Аннотация
INTRODUCTION: Marijuana (cannabis) use has become increasingly prevalent worldwide, raising concerns about its potential long-term health effects, particularly on the respiratory system. While tobacco smoking is a well-established risk factor for lung cancer,the association between cannabis use and lung cancer risk remains unclear and controversial. This systematic review and meta-analysis of existing observational studies aimed to evaluate the potential relationship between marijuana use and the risk ofdeveloping lung cancer.
METHODS: A systematic search was conducted across PubMed, Web of Science, and Scopus to identify cohort and case-controlstudies up to September 2025. Studies were selected, relevant data were extracted, and statistically analyzed using effect sizes (ES)and 95% confidence intervals (CI). All analyses were conducted using STATA software.
FINDINGS: This meta-analysis included six observational studies, comprising 16 effect sizes, consisting of two cohort studies andfour case-control studies. The pooled analysis of the cohort studies (7 effect sizes) indicated a statistically significant associationbetween marijuana (cannabis) smoking and increased lung cancer risk (ES: 2.06; 95% CI: [1.04-4.07]; P=0.038; I2=75%). Incontrast, the meta-analysis of the case-control studies (9 effect sizes) showed a non-significant increase in risk (ES: 1.16; 95% CI:[0.71-1.88]; P=0.542; I2=82%).
CONCLUSION: This meta-analysis indicates that marijuana smoking may increase lung cancer risk, with cohort studies showing asignificant twofold association. Although case-control studies were not statistically significant, the upward trend highlights theimportance of considering cannabis use in lung cancer risk assessments and patient counseling.
METHODS: A systematic search was conducted across PubMed, Web of Science, and Scopus to identify cohort and case-controlstudies up to September 2025. Studies were selected, relevant data were extracted, and statistically analyzed using effect sizes (ES)and 95% confidence intervals (CI). All analyses were conducted using STATA software.
FINDINGS: This meta-analysis included six observational studies, comprising 16 effect sizes, consisting of two cohort studies andfour case-control studies. The pooled analysis of the cohort studies (7 effect sizes) indicated a statistically significant associationbetween marijuana (cannabis) smoking and increased lung cancer risk (ES: 2.06; 95% CI: [1.04-4.07]; P=0.038; I2=75%). Incontrast, the meta-analysis of the case-control studies (9 effect sizes) showed a non-significant increase in risk (ES: 1.16; 95% CI:[0.71-1.88]; P=0.542; I2=82%).
CONCLUSION: This meta-analysis indicates that marijuana smoking may increase lung cancer risk, with cohort studies showing asignificant twofold association. Although case-control studies were not statistically significant, the upward trend highlights theimportance of considering cannabis use in lung cancer risk assessments and patient counseling.