Journal of diabetes · 2026
Advanced Cardiovascular-Kidney-Metabolic Risk and Risk-Factor Control in Patients With Type 2 Diabetes Without Established Cardiovascular Disease.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Dang Hai Nguyen Ngoc, Le The Trung, Pham Anh Kiem, Le Linh Duy, Nguyen Nam Van Duc, Tran Thanh Thien, Le Thinh Ba, Le Ny Ha Tuyet, Van Le Nam, Tran Hau Phuc, Vu Hung Minh, Tran Duong Hung, Thi Bich Ngoc Hoang, Pham Huy Nhu, Le Hieu Minh, Doan Thang Chi, Ho Binh Anh, Hoang Tien Anh, Van Huynh Minh, Luong Thang Viet
Аннотация
BACKGROUND: Cardiovascular-kidney-metabolic (CKM) risk stratification may identify patients with type 2 diabetes mellitus (T2DM) who require more intensive primary prevention, but real-world data from Vietnam are limited. We aimed to describe advanced CKM risk and risk-factor control in Vietnamese patients with T2DM without established cardiovascular disease (CVD).
METHODS: This multicenter cross-sectional study enrolled 1436 adults with T2DM without CVD in Vietnam. Advanced CKM risk was defined as 10-year total CVD risk ≥ 20% or eGFR < 60 mL/min/1.73 m2. Guideline-based control of HbA1c, blood pressure, LDL-C, triglycerides, and non-HDL-C was evaluated. Logistic regression assessed associations between advanced CKM risk and target achievement.
RESULTS: Advanced CKM risk was identified in 551 patients (38.4%). Despite a relatively low prevalence of BMI ≥ 25 kg/m2 (26.9%), hypertriglyceridemia was the most common metabolic abnormality, affecting 88.0% of participants. Risk-factor control was generally low, with 33.3% achieving glycemic control, 33.5% blood pressure control, 18.8% LDL-C control, 12.0% triglyceride control, and 21.1% non-HDL-C control. After adjustment, advanced CKM risk was associated with poorer blood pressure control (adjusted OR = 0.466, 95% CI = 0.359-0.603, p < 0.001) and triglyceride control (adjusted OR = 0.677, 95% CI = 0.473-0.969, p = 0.033), but not with achievement of HbA1c, LDL-C, non-HDL-C, or combined lipid control.
CONCLUSIONS: Advanced CKM risk was common among Vietnamese patients with T2DM without established CVD and was consistently associated with poorer blood pressure control. CKM-based risk assessment may identify high-risk patients earlier and support guideline-directed risk-factor management. Frequent hypertriglyceridemia with relatively low obesity supports a CKM-based strategy tailored to this metabolic risk pattern.
METHODS: This multicenter cross-sectional study enrolled 1436 adults with T2DM without CVD in Vietnam. Advanced CKM risk was defined as 10-year total CVD risk ≥ 20% or eGFR < 60 mL/min/1.73 m2. Guideline-based control of HbA1c, blood pressure, LDL-C, triglycerides, and non-HDL-C was evaluated. Logistic regression assessed associations between advanced CKM risk and target achievement.
RESULTS: Advanced CKM risk was identified in 551 patients (38.4%). Despite a relatively low prevalence of BMI ≥ 25 kg/m2 (26.9%), hypertriglyceridemia was the most common metabolic abnormality, affecting 88.0% of participants. Risk-factor control was generally low, with 33.3% achieving glycemic control, 33.5% blood pressure control, 18.8% LDL-C control, 12.0% triglyceride control, and 21.1% non-HDL-C control. After adjustment, advanced CKM risk was associated with poorer blood pressure control (adjusted OR = 0.466, 95% CI = 0.359-0.603, p < 0.001) and triglyceride control (adjusted OR = 0.677, 95% CI = 0.473-0.969, p = 0.033), but not with achievement of HbA1c, LDL-C, non-HDL-C, or combined lipid control.
CONCLUSIONS: Advanced CKM risk was common among Vietnamese patients with T2DM without established CVD and was consistently associated with poorer blood pressure control. CKM-based risk assessment may identify high-risk patients earlier and support guideline-directed risk-factor management. Frequent hypertriglyceridemia with relatively low obesity supports a CKM-based strategy tailored to this metabolic risk pattern.