MedElevator
Войти в исследования Journal of the science of food and agriculture · 2026
Nanoencapsulation of phycocyanin peptides enhances anti-inflammatory activity and alleviates ulcerative colitis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Zongyu, Du Shuang, Chen Yunlong, Dai Jing, Xu Guojing, Yin Hailin, Lv Liangtao
Аннотация
BACKGROUND: Ulcerative colitis (UC) is a prevalent inflammatory bowel disease, and current medications have considerable side effects. Phycocyanin peptides (PCPs) have demonstrated anti-inflammatory potential; however, their clinical application is limited by poor stability and low bioavailability. This study prepared highly active PCPs via ultrasound-assisted enzymatic hydrolysis and used chitosan-sodium tripolyphosphate nanoencapsulation to improve their application performance.
RESULTS: PCPs significantly inhibited nitric oxide release in lipopolysaccharide-induced RAW264.7 cells. The encapsulation efficiency of phycocyanin peptide nanoparticles (PCP-NPs) reached 91.33%, with markedly enhanced gastrointestinal stability and bioavailability. In mouse experiments, PCP-NPs reduced the disease activity index of ulcerative colitis mice, repaired colonic injury, down-regulated pro-inflammatory cytokines, and up-regulated anti-inflammatory cytokines and intestinal tight junction proteins. Three core anti-inflammatory peptides, YAINA, FPYTT, and YVTYA, were isolated and identified.
CONCLUSION: Nanoencapsulation strengthens the anti-inflammatory activity and intestinal barrier repair capacity of PCPs, which hold promising application potential as functional food ingredients for ulcerative colitis prevention. © 2026 Society of Chemical Industry.
RESULTS: PCPs significantly inhibited nitric oxide release in lipopolysaccharide-induced RAW264.7 cells. The encapsulation efficiency of phycocyanin peptide nanoparticles (PCP-NPs) reached 91.33%, with markedly enhanced gastrointestinal stability and bioavailability. In mouse experiments, PCP-NPs reduced the disease activity index of ulcerative colitis mice, repaired colonic injury, down-regulated pro-inflammatory cytokines, and up-regulated anti-inflammatory cytokines and intestinal tight junction proteins. Three core anti-inflammatory peptides, YAINA, FPYTT, and YVTYA, were isolated and identified.
CONCLUSION: Nanoencapsulation strengthens the anti-inflammatory activity and intestinal barrier repair capacity of PCPs, which hold promising application potential as functional food ingredients for ulcerative colitis prevention. © 2026 Society of Chemical Industry.