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DOI 10.1007/s11427-025-3356-1

Медицинская библиотека · Science China. Life sciences · 2026

Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.

Ren Yixuan, Yang Lei, Fei Boyi, Guo Rong, Huang Junran, Xu Zhenghao, Wang Ruoran, Zhang Pinqi, Cao Dandan, Chen Pan, Chen Yingxi, Cui Yingzi, Gao Qing, He Bo, He Jiangping, Hu Gongcheng, Jin Feng, Li Yanhe, Liu Dongdong, Liu Xin, Liu Xinyi, Liu Yanjiang, Liu Yunzhi, Luo Zhuojuan, Lu Yuxiao, Qi Jie, Wang Mingzhu, Wang Yiyun, Wen Junfei, Zhu Jacqueline Jufen, Chen Chong, Chen Jiekai, Cheng Albert Wu, Ding Junjun, Du Peng, Gou Lan-Tao, Han Jing-Dong Jackie, Li Haitao, Lin Chengqi, Liu Mo-Fang, Liu Wenqiang, Liu Xiaoyu, Mao Zhiyong, Miao Yi-Liang, Qu Jing, Qi Wei, Wu Min, Wu Xudong, Wong Jiemin, Yi Chengqi, Yue Rui, Zhang Na, Zhang Weiqi, Zhang Yong, Zhao Shuai, Zhu Dahai, Yao Hongjie, Du Hai-Ning, Lin Haiyan, Wu Zeming, Xu Qianhua, Gao Yawei, Chen Mo, Li Guohong, Liu Guang-Hui, Meng Zhuo-Xian, Xie Wei, Zhu Bing, Gao Shaorong

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Аннотация

Epigenetics, defined as the regulatory mechanisms that modulate genetic information flow without altering the DNA sequence, plays a crucial role in development, aging, and disease. This review explores the key epigenetic mechanisms-DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs-and their contributions to cellular differentiation, tissue homeostasis, and disease progression. We focus on their roles in gametogenesis, early development, stem cell reprogramming, and aging, highlighting how epigenetic alterations influence health and disease. The review also discusses emerging therapeutic approaches targeting epigenetic modifications, with potential applications in disease treatment and longevity. Finally, we examine the future of epigenetic research, emphasizing the need for precision therapies and the integration of epigenetic tools in clinical practice.

Для цитирования: Ren Yixuan, Yang Lei, Fei Boyi, Guo Rong, Huang Junran, Xu Zhenghao, Wang Ruoran, Zhang Pinqi, Cao Dandan, Chen Pan, Chen Yingxi, Cui Yingzi, Gao Qing, He Bo, He Jiangping, Hu Gongcheng, Jin Feng, Li Yanhe, Liu Dongdong, Liu Xin, Liu Xinyi, Liu Yanjiang, Liu Yunzhi, Luo Zhuojuan, Lu Yuxiao, Qi Jie, Wang Mingzhu, Wang Yiyun, Wen Junfei, Zhu Jacqueline Jufen, Chen Chong, Chen Jiekai, Cheng Albert Wu, Ding Junjun, Du Peng, Gou Lan-Tao, Han Jing-Dong Jackie, Li Haitao, Lin Chengqi, Liu Mo-Fang, Liu Wenqiang, Liu Xiaoyu, Mao Zhiyong, Miao Yi-Liang, Qu Jing, Qi Wei, Wu Min, Wu Xudong, Wong Jiemin, Yi Chengqi, Yue Rui, Zhang Na, Zhang Weiqi, Zhang Yong, Zhao Shuai, Zhu Dahai, Yao Hongjie, Du Hai-Ning, Lin Haiyan, Wu Zeming, Xu Qianhua, Gao Yawei, Chen Mo, Li Guohong, Liu Guang-Hui, Meng Zhuo-Xian, Xie Wei, Zhu Bing, Gao Shaorong. Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.. Science China. Life sciences. 2026. DOI: 10.1007/s11427-025-3356-1.
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