8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines).
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Cardoso Fatima, Ribeiro Joana Mourato, Schumacher-Wulf Eva, Swain Sandra M, Paluch-Shimon Shani, Penault-Llorca Frederique, Lin Nancy U, Francis Prudence A, Kuper-Hommel Marion, May Anne, Hilbers Florentine, Guerrero Angel, Aapro Matti S, Azmi Rania, Bajpai Jyoti, Barrios Carlos, Biganzoli Laura, Boyle Fran, Caceres Valeria, Carey Lisa A, Chavez-MacGregor Mariana, Cortés Javier, Dent Rebecca, Drury Amanda, El Saghir Nagi S, Elghazaly Hesham, Eniu Alexandru, Fallowfield Lesley, Franco Millan Sandra Ximena, Gelmon Karen, Gilchrist Jenny, Gligorov Joseph, Gradishar William J, Harbeck Nadia, Hu Xichun, Kaidar-Person Orit, Kaur Ranjit, Kiely Belinda, Kim Sung-Bae, Nyagabona Sarah Kutika, Lustberg Maryam, Mueller Volkmar, Mutebi Miriam, Neciosup Silvia, Ohno Shinji, Pistilli Barbara, Rugo Hope S, Spanic Tanja, Tsang Janice, Vuylsteke Peter, Xu Binghe, Norton Larry, Winer Eric P
Аннотация
The Advanced Breast Cancer (ABC) 8th international consensus conference took place on 6-8 November 2025, in Lisbon, and updated the previous ABC international consensus guidelines that are described in this manuscript. These guidelines reflect the work of a large and global consensus panel, comprising healthcare professionals and patients, and provide recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes. The guidelines are based on the best available evidence or on expert opinion when a higher level of evidence is lacking and aim to cover the needs of the person living with ABC, including but also beyond the main therapeutic recommendations. Each guideline is accompanied by the level of evidence (LoE), the grade of recommendation (GoR), and the percentage of consensus reached at the consensus session. Updated diagnostic and treatment algorithms are also provided. These guidelines are endorsed by several international oncology organizations (AGO, AORTIC, ECO, EONS, ESO, ESTRO, EUSOMA, GECO Perú, SUMA, MASCC, French Breast Cancer Guidelines and AMAAC) and have official representation from ASCO, NCCN and ABC-NZ. Inequalities in access to high-quality care have increased in the last decade, both between and within countries, and are a major concern. The ABC guidelines provide guidance on the best available management options for patients living with ABC globally, assuming availability of the recommended therapies. Their adaptation is often needed in resource-constrained settings, and the grading of each recommendation may help in prioritizing access to available options.