Alzheimer's & dementia (Amsterdam, Netherlands) · 2026
Associations of mild behavioral impairment and white matter hyperintensity patterns.
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Linha Zdenek, Dolezal Rafael, Seifert Matej, Ravi Tejasvi, Ismail Zahinoor, Kearns Pavla Brennan, Alzheimer's Disease Neuroimaging Initiative
Аннотация
INTRODUCTION: It is unclear whether cerebrovascular and white matter changes contribute to mild behavioral impairment (MBI). White matter hyperintensities (WMHs) represent a prominent pathology for research due to association with cognitive decline. We investigated associations between MBI measures and WMH volume and spatial distribution.
METHODS: We analyzed 1273 individuals with normal cognition or mild cognitive impairment. General linear models and voxel-wise analyses were employed to examine WMHs in terms of volume and spatial distribution.
RESULTS: Greater WMH volume was associated with higher MBI total score and MBI status in participants with normal cognition and mild cognitive impairment. Voxel-wise analysis revealed a significant cluster in the left inferior longitudinal fasciculus associated with higher MBI total score.
DISCUSSION: Our findings suggest a contribution of WMH volume and spatial distribution to persistent later-life behavioral symptoms. WMHs, especially in the left inferior longitudinal fasciculus, may serve as a neuroimaging marker of behavioral symptoms.
METHODS: We analyzed 1273 individuals with normal cognition or mild cognitive impairment. General linear models and voxel-wise analyses were employed to examine WMHs in terms of volume and spatial distribution.
RESULTS: Greater WMH volume was associated with higher MBI total score and MBI status in participants with normal cognition and mild cognitive impairment. Voxel-wise analysis revealed a significant cluster in the left inferior longitudinal fasciculus associated with higher MBI total score.
DISCUSSION: Our findings suggest a contribution of WMH volume and spatial distribution to persistent later-life behavioral symptoms. WMHs, especially in the left inferior longitudinal fasciculus, may serve as a neuroimaging marker of behavioral symptoms.