A report on the 2025 global conference on research and application of Chinese herbal medicine-derived extracellular vesicles.

This conference report summarizes the Global Conference on Research and Application of Chinese herbal Medicine Derived Extracellular Vesicles-like Particles (CHM-EVLPs) held in Guangzhou. The conference gathered worldwide scholars to exchange cutting-edge advances in extracellular vesicle (EV) extraction, functional modification, disease treatment, and industrial transformation via six themed forums covering basic research, fruit EVLPs, laboratory testing, HIV intervention, and youth innovation. Experts shared standardized separation technologies, engineered modification strategies and multi-target therapeutic potentials of plant-derived extracellular vesicles (PDVs) against tumors, intestinal disorders, metabolic diseases and neurodegenerative injuries, while discussing key bottlenecks including large-scale production, quality control and regulatory guidelines. Cross-kingdom molecular communication, oral nano-delivery systems and interdisciplinary combinations with microneedles and artificial intelligence were highlighted as promising research directions. The event promoted international academic cooperation, clarified translational challenges of CHM-EVLPs products, and laid a foundation for advancing standardized, industrialized and globalized development of PDVs to facilitate worldwide medical care improvement.