iGIE : innovation, investigation and insights · 2025
Risk factors linked to gastric intestinal metaplasia in adults from a private clinic in the Dominican Republic.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Socias-Pappaterra Pablo, Ebrahim Ibrahim Yousef S, Ho Sang Vivian, Moquete Grullon Beatriz, Romano Ramon, Contreras Fernando
Аннотация
BACKGROUND AND AIMS: Gastric intestinal metaplasia (GIM) significantly increases the risk of developing future gastric cancer by 6-fold. This study aimed to identify the most common risk factors associated with GIM in adults who underwent EGD at a private clinic in the Dominican Republic.
METHODS: This retrospective cohort study examined the risk factors of GIM in adults who underwent esophagogastroduodenoscopy (EGD) at a private clinic in the Dominican Republic in 2024. Indications included dyspepsia, gastroesophageal reflux disease (GERD), surveillance of premalignant lesions, combined lower and upper gastrointestinal screening, and alarm symptoms. All procedures followed the Sydney biopsy protocol, with additional biopsy specimens from areas concerning for GIM. Experienced pathologists reviewed biopsy specimens and diagnosed GIM histologically. Patient data and biopsy results were obtained from electronic medical records, and logistic regression identified independent risk factors for GIM.
RESULTS: Of the 781 patients, 14.6% had GIM. Multivariate odds ratio (MultivOR) analysis indicated that current Helicobacter pylori (H pylori) infection (MultivOR, 3.51; 95% confidence interval [CI], 2.01-6.10), past H pylori infection (MultivOR, 2.61; 95% CI, 1.63-4.16), and age (MultivOR, 1.06; 95% CI, 1.04-1.08) were linked to an increased risk of GIM. Other factors showed no significant association.
CONCLUSIONS: Current and past H pylori infections and age increase GIM risk for both extensive and limited GIM in adults undergoing EGD at a Dominican clinic. Further studies are needed to evaluate their relevance for gastric cancer screening strategies.
METHODS: This retrospective cohort study examined the risk factors of GIM in adults who underwent esophagogastroduodenoscopy (EGD) at a private clinic in the Dominican Republic in 2024. Indications included dyspepsia, gastroesophageal reflux disease (GERD), surveillance of premalignant lesions, combined lower and upper gastrointestinal screening, and alarm symptoms. All procedures followed the Sydney biopsy protocol, with additional biopsy specimens from areas concerning for GIM. Experienced pathologists reviewed biopsy specimens and diagnosed GIM histologically. Patient data and biopsy results were obtained from electronic medical records, and logistic regression identified independent risk factors for GIM.
RESULTS: Of the 781 patients, 14.6% had GIM. Multivariate odds ratio (MultivOR) analysis indicated that current Helicobacter pylori (H pylori) infection (MultivOR, 3.51; 95% confidence interval [CI], 2.01-6.10), past H pylori infection (MultivOR, 2.61; 95% CI, 1.63-4.16), and age (MultivOR, 1.06; 95% CI, 1.04-1.08) were linked to an increased risk of GIM. Other factors showed no significant association.
CONCLUSIONS: Current and past H pylori infections and age increase GIM risk for both extensive and limited GIM in adults undergoing EGD at a Dominican clinic. Further studies are needed to evaluate their relevance for gastric cancer screening strategies.